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Alongside one another, these facts counsel that integrin αvβ3 receptors dynamically regulate SERT uptake exercise and place to novel pathways that may be qualified pharmacologically with the amelioration of five-HT-dependent deficits in adult animals.
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max in WT synaptoneurosomes, suggesting that Src signaling could be downregulated in KI synapses. Conversely, our power to rescue SERT purpose in KI midbrain synaptoneurosomes by the inhibition of FAK implies elevated FAK signaling downstream of the Pro32Pro33 mutant, as verified by greater pFAK localization in 5-HT synapses. Our facts hence advise which the Src–FAK pathway is uncoupled by constitutive activation of integrin βthree, and therefore Each individual kinase may very well be influencing SERT independently.
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